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Public
Health & the Future of Medicine
The
return of ancient scourges like plague and the emergence of such
new ones as AIDS have thrust Yale's Department of Epidemiology and
Public Health into the medical spotlight. Under a new dean, the
department is helping to rethink the way humanity battles disease.
December
1996
by Bruce Fellman
The spring
of 1972 found the SS Hope, a floating hospital ship, anchored in
the harbor of Natal, an impoverished town on the northeast coast
of Brazil. On
board was Michael
H. Merson, a medical resident at Johns Hopkins with a deepening
interest in the health-care issues of the developing world. "I
wanted to know more about diseases you didn't see at Hopkins, and
I wasn't disappointed," says Merson, who last April was named
Yale's first dean of public health and director of the medical school's
department of epidemiology
and public health (EPH). "I dealt with all sorts of ailments:
malaria, schistosomiasis, typhoid, leprosy -- Natal was a museum of
tropical illnesses."
And then some. Infant
mortality was appallingly high. Family income was low. Each day's
roster of the infirm conveyed an unavoidable message. "The
society these people lived in was making them sick," recalls
Merson. "In Brazil, I got to see first-hand the relationship
between health, social, and economic problems. That experience made
me want to go into public health."
Twenty-three years later,
and after stints at the U.S.
Centers for Disease Control in Atlanta and at the World
Health Organization in Geneva, Merson, 50, comes to Yale to
direct an institution that, like healthcare itself, is undergoing
a period of rapid change, not to mention soul-searching. "Mike's
an outstanding public health activist and a real leader who can
help EPH develop a consensus about its direction," says Gerald
Burrow, dean of the Medical School. "The program here can't
be all things to all people."
Burrow's statement reflects
a problem that goes back to the very beginnings of the discipline,
which traces its origins
at Yale to 1915. In that year, Charles-Edward Amory Winslow became
the Anna M. R. Lauder Professor of Public Health. (Winslow, incidentally,
had studied with, and worked for, William Sedgwick, Class of 1877S,
who had taught at the Medical School before starting the nation's
first public health school at M.I.T.,
in 1906.) In establishing Winslow's department, the University bucked
both a trend and the recommendation of the Rockefeller Commission.
Schools of public health, said those who had inaugurated them and
those who were evaluating the enterprises, should remain separate
institutions. Such was the case at M.I.T., Harvard, Johns Hopkins,
and elsewhere, but at Yale (and also at George Washington University),
public health was made a department of the medical school -- precisely
the situation the Rockefeller Commission sought to avoid for fear
that the discipline -- which deals with the health of populations
-- would be overshadowed by medicine, which is concerned primarily
with the health of individuals. (Epidemiology, the study of the
factors that affect the occurrence of a disease in any population,
was added to the department's name in 1960.)
While
this unusual arrangement worked well for decades,
the occasion of a major -- though routine, say officials -- review
of the program in the late 1980s had many in the department uncertain
about EPH's future. However, the work of a study group headed by
then-provost Frank Turner in 1989 resulted in the University's reaffirming
its commitment to the discipline. Six years after the Turner Commission
issued its report, the school has revamped its curriculum, tightened
admissions standards, and begun to overhaul its Philip
Johnson-designed headquarters on College
Street. The most conspicuous sign of Yale's renewed faith in
the future of EPH is not only that it has hired someone of Merson's
stature to run the program, but that it has granted him the title
of dean, which (except for engineering) is reserved for heads of
free-standing schools rather than departments.
At the moment, Merson's
department has more than four dozen full-time faculty members and
nearly 200 graduate students
who work and train in six distinct areas -- chronic disease epidemiology;
health policy, resources, and administration; environmental health
sciences; international health; the microbiology and epidemiology
of infectious diseases; and biostatistics. Where the new dean intends
to lead his organization, however, is currently under debate.
"This is an exciting
and challenging time to be in public health," says Merson.
Indeed, the entire health-care delivery system of the United States
is undergoing revolutionary change, so there is health-care policy
to effect and analyze. The recent outbreaks of Ebola in Africa and
plague in India, as well as the reemergence of tuberculosis in American
cities and the continuation of the AIDS epidemic, are reminders
of the urgency of the need.
That public health in
general and EPH in particular have important roles to play in dealing
with these and related issues has never been more obvious, says
Henry Chauncey Jr., who joined the EPH faculty as director of its
program in health policy administration after serving as president
of the Gaylord
Hospital, a Wallingford, Connecticut, facility that specializes
in rehabilitation. "It's axiomatic that if you want to cut
the costs of health care, you need to have less illness and increase
the quality and availability of care," notes Chauncey. "Public
health holds the answers."
To determine which answers
EPH is in the best position to provide, Merson has instituted a
top-to-bottom review by faculty and administrators of everything
the school does. "We've always provided a solid education in
public health that focused on epidemiological methods, and since
we started, we've been on the cutting edge of research. This will
certainly continue," he says. But to take advantage of new
opportunities, a certain amount of change is also necessary, and
while it is too early in the review process to know precisely where
the institution is headed, its new dean has singled out a number
of areas to explore.
"Last
year, the federal government made an effort to draft a national
health care plan, which, as we all know, wasn't accepted,"
says Merson. "In its absence, market, social, and political
forces have moved forward to quickly bring more and more people
under a managed care framework. Trying to figure out whether or
not these rapidly evolving systems of managed care are cost-effective
and efficient is now becoming a public health responsibility. We
need to be involved."
The prevention of disease
has been a key part of the discipline since its inception, and here
too, managed care systems have to be watched carefully to ensure
that they don't stint on this critical function. "We're now
reaping the benefits of prevention research of the past 30 years,
research that has shown that 70 percent of mortality can be viewed
as premature," says Merson. "So another challenge is determining
how we should organize our approach to prevention in a managed care
context."
Then there is the aging
U.S. population to consider. "How do we best care for the aged?"
asks the dean. "How do we prevent diseases and age-related
ailments like broken bones due to falls? How do we deal with the
dying? These are certainly issues public health needs to deal with."
EPH researchers are
already working in this area, as they are in another topic on the
dean's agenda: emerging and re-emerging infectious diseases, as
well as noninfectious ailments like asthma and Alzheimer's disease.
"For reasons we don't always understand, we're getting new
problems, old ones are resurfacing, and uncommon illnesses are becoming
more common," Merson notes. "We in public health need
to figure out why."
Figuring that out falls
within the traditional domain of epidemiology; understanding how
to prevent the ailments they cause is a key part of the public health
discipline. Merson would like to bring both parts of the EPH arsenal
to bear on a problem Yale is already involved in: eradicating urban
decay. "A challenge for us is how to help get healthy cities,"
he notes. "It's not enough to ensure that there's access to
good health-care systems and preventive services. We also have to
play a role in designing interventions that deal with the major
social factors that affect the population. Why are people violent?
Why is there drug abuse? These are not just medical questions, and
if we're ever going to solve them, we need to adopt a broader view
of health."
In the current health-care
climate, the fact that EPH is part of the Medical School, rather
than in competition with it, is a major advantage, says William
Kissick '53, '57MD, '61DPH, the George Seckel Pepper Professor
of Public Health and Preventive Medicine at the University of Pennsylvania.
Kissick, one of the fathers of Medicare,
is a strong proponent of linkage. "No society in the world
has sufficient resources to provide all the health services its
population could utilize, so real health-care reform will require
the application of public health principles to medical practice,"
he explains. "Each discipline desperately requires the other."
Such
a synthesis already has a long, if sometimes strained, working history
at Yale, but the
strains seem to be easing in an era when, according to Merson, "the
line between medicine and public health is becoming less and less
clear." There is, for example, a Clinical Scholars Program
in the Medical School in which physicians are studying how to provide
better treatment by understanding epidemiology and policy issues.
Another example of the advantages of togetherness occurred during
the curricular changes inaugurated in the early 1990s. At that time,
faculty members decided that it was critical for students in the
two-year master of public health degree program to understand the
basics of molecular biology. "At the very least, they should
be able to distinguish a bacterium from a virus," said Michael
Bracken, a professor of epidemiology and public health who was
instrumental in putting together the new curriculum. (Unlike many
schools, Yale requires both a thesis and a community project.) Because
of Yale's "extraordinary strengths in molecular medicine,"
developing such a course was relatively easy, says Bracken.
More such "bridge-building"
efforts will, Merson predicts, enable EPH researchers to move quickly
into new areas by drawing on the existing resources of other graduate
and professional schools, as well as on those of Yale College. The
advantages of this integrated approach appealed to the Pew
Charitable Trusts, which recently awarded EPH a $300,000 grant
to develop a course being offered this semester on urban health.
The program is designed to bring together medical, public health,
and nursing students to work on problems that might best be solved
by combining the strengths of both groups. Similar initiatives are
underway between EPH and the School
of Forestry and Environmental Studies, with the Child Study
Center, with the John B. Pierce Laboratory, and with the
School of Management. The collaboration with SOM involves the
development of a new health-care management track for master's degree
students. "We've been very strong in hospital management training,"
says Merson, "but managed care will require professionals who
can deal with much more than just hospitals."
Clearly, the discipline
is changing, but in deciding how to respond, Theodore
R. Marmor, a professor at the School of Management, offers words
of caution. "I hope Merson won't get so caught up in trying
to do the highly desirable that he pays no attention to the doable
and to the legacy of public health," says Marmor.
There
is probably little likelihood of that happening,
for Merson is nothing if not well-grounded in the basics of the
discipline (even though, ironically enough, he has no degrees in
public health). Growing up in Brooklyn, the dean was heavily influenced
in his career path by his grandfather, a cardiologist who had the
boy drawing blood while still in high school. At Amherst College,
Merson majored in biology, but he also pursued studies in political
science and government. "I've long been interested in a broader
view of health -- in issues of social justice and equity, as well
as in medicine," says Merson.
These dual concerns
came together for the first time in 1969 when, after his junior
year at the State University of New York's medical school in Brooklyn,
he landed in New Delhi en route to a summer of family-planning work
in Nepal. "I'll never forget the smells of the Indian food
or the beautiful colors of the saris," Merson recalls, adding
that in and around Katmandu, "I did vasectomies, inserted IUDs,
and conducted a survey on what services were available. It was in
the Himalayas that I got bitten by the international health bug."
That experience, and
his service on the SS Hope, showed Merson that while advances
in medical research were able to provide treatments for many diseases,
medicine, by itself, could not cure what ailed the developing world.
Poverty, environmental degradation, development, and a simple lack
of information -- all of these had to be dealt with as well.
Merson's opportunity
to tackle the "broad spectrum of public health issues"
came in 1977 when he became the chief medical epidemiologist at
the Cholera
Research Laboratory in Dhaka, Bangladesh. After finishing his
residency, the physician had been working under the auspices of
the U.S. Centers for Disease Control and had, in the course of publishing
numerous papers on such topics as "gastrointestinal illness
on passenger cruise ships" and "toxic
turista," become one of the leading experts in diarrheal
diseases. In this country such ailments often fall under the category
of nuisances -- unpleasant but rarely life-threatening -- but in
Third World nations like Bangladesh, says Merson, these diseases
were, when he began his work, "the major killer of young people."
Two breakthroughs
began to change that.
In the early 1970s, microbiologists were finally able to identify
many of the organisms that caused the various forms of diarrhea.
This development allowed researchers like Merson to begin to understand
the epidemiology of the ailment and thus to craft prevention strategies.
At about the same time, a team of investigators and physicians (some
of them from Yale) were perfecting oral
rehydration therapy (ORT), a relatively cheap and easy way to
prevent the dehydration and malnutrition that together cost the
lives of many diarrhea victims.
In Bangladesh, Merson
helped bring both innovations to bear on the health of a beleaguered
population, and the results were quickly apparent. "We demonstrated
that most cases of diarrhea were infectious in origin -- believe it
or not, that was controversial back then -- and that they were treatable
with ORT and antibiotics," he said.
The World
Health Organization at the United Nations took notice, and in
1978, Merson was invited to join WHO's Diarrheal Diseases Control
Programme, which was based in Geneva, and whose scope was world-wide.
"We developed a very comprehensive approach," Merson says,
noting that in addition to pushing for advances in basic science
and in the availability of ORT, the organization had a wide range
of other items on its agenda: pure water, improved hygiene, vaccine
development, and encouraging mothers to breast-feed their children
for at least the first two years of life.
"As a result of
what we did, at least a million childhood deaths a year were averted,"
says Merson, who became the program's director in 1984 and was asked
in 1987 to tackle another major child-killer, pneumonia.
"In this country,
when you want to diagnose the disease, you listen with a stethoscope
and take an X-ray," said the physician. In much of the developing
world, however, even the most basic medical equipment is frequently
unavailable. But research done in the 1980s showed that a reasonably
correct diagnosis could still be arrived at by the most low-tech
of means: counting the number of breaths a child took and watching
the way he or she breathed. "With two simple observations,
you could determine which kid needed antibiotics and which kid didn't,"
says Merson. "True, there was a tendency to overtreat, but
with this approach, we estimated that deaths from pneumonia could
be reduced by two-thirds."
Flush with similar successes
around the world, medical optimists had begun speculating that it
would soon be possible to declare a victory over infectious diseases.
Then came AIDS.
WHO responded to the
epidemic with its Global
Programme on AIDS, and in 1990, Merson was asked to head what
was then a $100 million effort that employed 450 people. "This
terrible disease poses the greatest threat to health on the planet,
and for me, all the reasons I went into public health came together
in running the program," says the physician. "I was involved
in setting policy, long-range planning, supporting research, and
evaluation. The job challenged my total public health self, and
we had some real successes. In five years, we achieved a worldwide
consensus that AIDS is truly a global health problem, and that it
can affect every segment of society. We've shown that we can control
the incidence of AIDS by teaching people to make changes in their
behavior."
Despite
such efforts, however, the number of people infected with the virus
that causes AIDS continues to grow,
and by this year, it had become clear at WHO that "the epidemic
had become too big for any one UN agency to handle alone,"
says Merson, who, after 17 years in Geneva running three global
health programs, was also contemplating a change. "I'd traveled
to more than 100 countries, and I'd seen their problems first hand.
I wanted to play a role in getting people to come into public health
-- in training and educating future leaders, in influencing the
field's research agenda, and in being an advocate."
Yale, it turned out,
had an opening. The chemistry was good. The University was close
to the home base of Merson's favorite basketball team, the New York
Knicks (the dean, captain of his college basketball team, also played
soccer and baseball, and is now a swimmer). Merson, his wife Claudia
-- a bilingual curriculum development specialist who is working
at the new Career High School -- and his son Jonathan, now a freshman
at the College, moved from Geneva to New Haven.
With his family well
ensconced in the Elm City and his office looking a little less spare,
Merson reflected on a remark he'd made last spring when he addressed
his constituency for the first time. "I firmly believe that
EPH is a hidden treasure in this University and this country,"
the dean had said.
Merson, particularly
after his tenure in the WHO AIDS "hot seat," is nothing
if not expert at getting the print and broadcast world to take notice
of "hidden treasure." (Indeed, he has been to school to
learn the art of getting his point across in the media, where he's
been interviewed everywhere from the New York Times to Good Morning
America.) So after the soul-searching effort Merson began is complete -- sometime
this winter, he estimates -- and the department begins implementing
the resulting changes, don't expect EPH to remain hidden much longer.
"There has never been a time when the challenges for public
health are as great as they are today," says the dean. "Yale
has a tremendous amount to offer toward solving these problems."
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