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Brain power
July/August 2008
by Emily Anthes '05
Pasko Rakic was asleep when his phone rang at 6 a.m. on May 28. "I was
still in bed, and I was thinking somebody wants to sell me something," he
recalls. But the voice on the other end informed Rakic, chair of the
neurobiology department at the medical school, that he had won the first Kavli
Prize for Neuroscience, one of a new set of million-dollar scientific awards.
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Rakic has devoted his career to studying the development of the cerebral cortex.
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This year's prizes are the first in what will be a
set of biennial honors going to leading researchers in neuroscience,
nanoscience, and astrophysics. The prizes are sponsored jointly by the Kavli
Foundation, the Norwegian Academy of Science and Letters, and the Norwegian
Ministry of Education and Research. Rakic shares this year's neuroscience award
with two other scientists: Thomas Jessell of Columbia University and Sten
Grillner of Sweden's Karolinska Institute.
Rakic
has devoted his career to studying the development of the cerebral cortex, the
wrinkled top layer of the brain responsible for higher cognitive functions such
as language. He has made a number of fundamental discoveries, including how new
neurons migrate to their final positions in the cortex. The brain cells that make
up the cortex are actually born deeper in the brain; Rakic showed that the
neurons are guided to their locations by a temporary scaffolding of living
cells and that newer neurons travel beyond older ones before coming to rest.
His work has helped explain how the cortex develops its hallmark layers.
Despite his record of significant findings, Rakic
knows that plenty of questions remain to be answered. "The human brain is the
most complex structure in the universe," he says. "I recognize that it will not
be finished with me. The next generation will be even more positioned to
understand where we come from and where we are going." 
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