Interior view
July/August 2007
Photograph by Julie Brown

There are many high-tech ways to
watch the body at work. Yale researchers are currently using this NeuroFocus
SPECT scanner, one of only five in the world, to search the brain for
chemical needles in a molecular haystack.
SPECT stands for single-photon
emission computed tomography. To image the brain with SPECT, researchers inject
a radioactive chemical tracer into a subject's bloodstream and then, with the
camera, watch the tracer's journey to the brain. Physicians routinely use SPECT
scans to detect tumors, locate the epicenters of seizures, and map the extent
of stroke damage. But Yale is applying the NeuroFocus scanner in basic
research. Scientists use it on animal subjects to test new radioactive tracers
for targeting specific brain chemicals that, in humans, are involved in
neuropsychiatric conditions as diverse as depression, schizophrenia, and drug
addiction.
"There are millions of chemicals in
the brain, but we have only a few tracers available for human use," says Julie
K. Staley, psychiatry professor and director of SPECT imaging. "We send in
specific keys and, with this scanner, make sure they go to the right locks." |